Sitemap - 2023 - Axial

Scientist Stories: Cynthia Kenyon, Staying Ahead of the Curve

Immune cell decoration

Scientist Stories: Uri Alon, The Mathematical Essence of Aging

Eikon Therapeutics

Scientist Stories: Sarah Teichmann, Global Principles of Protein Interactions and Gene Expression

Scientist Stories: Fabian Theis, ML in Single-Cell Genomics

LLMs and law

Learning by Observing

De novo development of small cyclic peptides that are orally bioavailable

Minimal Residual Disease (MRD)

Fate Therapeutics

Scientist Stories: William Schief, Structure Assisted Vaccine Discovery for Infectious Diseases

Scientist Stories: Euan Ashley, The Potential of Ultrarapid Nanopore Genome Sequencing for Medicine

Proteomics

RNA editing

Gene Yeo, RNA Processing & Regulation

De novo evolution of macroscopic multicellularity

Scientist Stories: Klaus Ley, Translating an Atherosclerosis Vaccine to Clinical Trials

Scientist Stories: Aaron Ring, Autoantibodies in COVID-19

Carmot Therapeutics

Scientist Stories: Euan Ashley, Data & Precision Health

Scientist Stories: Aly Khan, Computational Approaches to Study Immune Cells

Timothy Springer

Genetically encoded barcodes for correlative volume electron microscopy

Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration

Founder Stories: Adrian McDermott, Global Head of Immunology at Sanofi Vaccines

Paul Janssen

Sculpting conducting nanopore size and shape through de novo protein design

Inverse folding of protein complexes with a structure-informed language model enables unsupervised antibody evolution

Scientist Stories: Seema Lakdawala, Assembly of Viruses

Nanobody therapeutics

Sequential Optimal Experimental Design of Perturbation Screens Guided by Multi-modal Priors

De novo design of high-affinity binders of bioactive helical peptides

Trumpet is an operating system for simple and robust cell-free biocomputing

Drugging SARM1

Scientist Stories: Helder Nakaya, Systems Immunology

Antibodies for for Alzheimer’s disease

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Xencor

Scientist Stories: Nir Barzilai, Aging and Pandemics

The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA

Founder Stories: Laura Walker, Generation of Neutralizing Antibodies for Pandemics

Scientist Stories: Elaine Fuchs, Stem Cells and Medicine

Scientist Stories: Jack Szostak, The Origin of Life Not as Hard as it Looks

Peter Gassner and Veeva

Moderna (11/2/2023)

Knowde

An N terminomics toolbox combining 2-pyridine carboxaldehyde probes and click chemistry for profiling protease specificity

Proteomic discovery of chemical probes that perturb protein complexes in human cells

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Mapping the T cell repertoire to a complex gut bacterial community

An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4

Enzymatic Nitrogen Insertion into Unactivated C–H Bonds

Antibody pair matching

The History of Casgevy

Method for multiplexed detection of nucleic acids using spectrally encoded beads

Neumora Therapeutics

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Nicola Rieke, Federated Learning for Healthcare

John Stamatoyannopoulos, High Resolution Maps of Regulatory DNA

Uri Alon, Geometry of Phenotype Space

Matthew Rabinowitz, Co-Founder of Natera

Hans Clevers, Stem Cell based Organoids in Human Disease

Nicole Martinez, RNA Modifications & Rewriting the Message in Health & Disease

Evan Eichler, Long Read Sequencing of Complex Genomes

Kathryn Lilley, Probing the Spatial Proteome

Emmanuel Levy, Self-Organization in the Proteome

Julia Schnabel, AI-enabled imaging

Jean-Philippe Vert, Machine Learning for Single Cell Omics

Founder Stories: Kiran Mazumdar-Shaw, Founder & Chairman of Biocon

Scientist Stories: Cynthia Kenyon, Genetics of Aging

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The enteric nervous system relays psychological stress to intestinal inflammation

Scientist Stories: John Wherry, Systems Immunology and T-cell Exhaustion

Orbital Therapeutics

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

Yogi Berra, Yankee

Scientist Stories: Magdalena Zernicka-Goetz, Human Development and Synthetic Embryos

Scipher Medicine

Unraveling the origin of chirality from plasmonic nanoparticle-protein complexes

E.O. Wilson, Nature and Biodiversity

Founder Stories: Arie Belldegrun, Founder of Kite Pharma

Frances Arnold, Directed Evolution to Engineer Enzymes

Iambic Therapeutics

Biocatalytic, Intermolecular C−H Bond Functionalization for the Synthesis of Enantioenriched Amides

Scientist Stories: Frances Arnold, Directed Evolution and Protein Engineering

Dren Bio

Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Founder Stories: Peter Gassner, Co-Founder and CEO of Veeva

Scientist Stories: Euan Ashley, Outstanding Problems in Bioengineering

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

Tune Therapeutics

Founder Stories: Susan Desmond-Hellmann, Gates Foundation, UCSF & Genentech

Phage-assisted evolution and protein engineering yield compact, efficient prime editors

Halozyme Therapeutics

Scientist Stories: Nathalie Garçon, The Future of Adjuvants are mRNA Vaccines

Detecting chromatin interactions between and along sister chromatids with SisterC

Profluent Bio

Scientist Stories: Uri Hasson, Deep Neural Networks as Cognitive Models for the Brain

Scientist Stories: James Crowe, Monoclonal Antibodies for Infectious Diseases

Digest 9/28/23

Profiles in Biotech (9/28/23)

Scientist Stories: Terry Orr-Weaver, Cell Division and Chromosome Segregation

Digest 9/20/23

Profiles in Biotech (9/20/23)

Profiles in Biotech (9/19/23)

Profiles in Biotech (9/15/23)

Profiles in Biotech (9/14/23)

Profiles in Biotech (9/13/23)

Scientist Stories: John Stamatoyannopoulos, High Resolution Maps of Regulatory DNA

Digest 9/12/23

Profiles in Biotech (9/12/23)

Scientist Stories: Uri Alon, Geometry of Phenotype Space

Digest 9/11/23

Profiles in Biotech (9/11/23)

Profiles in Biotech (9/10/23)

Life Sciences Ideas (9/7/23)

Biotech Companies & Builders (9/7/23)

Founder Stories, Matthew Rabinowitz, Co-Founder of Natera

Digest 9/7/23

Profiles in Biotech (9/7/23)

Profiles in Biotech (9/5/23)

Profiles in Biotech (9/4/23)

Profiles in Biotech (9/3/23)

Profiles in Biotech (9/1/23)

Profiles in Biotech (8/31/23)

Profiles in Biotech (8/30/23)

Profiles in Biotech (8/29/23)

Scientist Stories: Hans Clevers, Stem Cell based Organoids in Human Disease

Digest 8/28/23

Review: "Is drug R&D more like poker or chess?"

Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets

Profiles in Biotech (8/28/23)

Scientist Stories: Feng Zhang, The Future of Gene Editing

Materials and methods for treatment of hemoglobinopathies

Regeneron

Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

Scientist Stories: Nicole Martinez, RNA Modifications & Rewriting the Message in Health & Disease

Digest 8/25/23

Scientist Stories: Evan Eichler, Long Read Sequencing of Complex Genomes

Digest 8/24/23

Scientist Stories: Kathryn Lilley, Probing the Spatial Proteome

Digest 8/23/23

Scientist Stories: Emmanuel Levy, Self-Organization in the Proteome

Digest 8/21/23

Scientist Stories: Nicola Rieke, Federated Learning for Healthcare

Digest 8/20/23

Scientist Stories: Jean-Philippe Vert, Machine Learning for Single Cell Omics

Digest 8/18/23

Scientist Stories: Julia Schnabel, AI-enabled imaging

Digest 8/17/23

Analysis 8/16/23

Scientist Stories: Scott Fraser, Multiplex Imaging of Cells in their Natural Contexts

Digest 8/16/23

Scientist Stories: Chloe Hsu, Deep Learning in Structural Biology & Protein Design

Digest 8/15/23

Scientist Stories: Manolis Kellis, Integrative Analysis of 10,000 Epigenomic Maps

Digest 8/14/23

Scientist Stories: Maria Maldonado, Structural Insights into Plant Respiration

Digest 8/13/23

Analysis 8/12/23

Scientist Stories: Jeff Vierstra, Footprinting the Human Genome

Digest 8/12/23

Analysis 8/11/23

Scientist Stories: Donna Farber, Human Anti-Viral Immunity in Tissue Sites

Digest 8/11/23

Scientist Stories: Aviv Regev, Building the Human Cell Atlas

Digest 8/10/23

Scientist Stories: Shawn Burgess, Translational Genome Editing

Digest 8/9/23

Scientist Stories: Johannes Textor, Immunological Intelligence

Digest 8/8/23

Scientist Stories: Hans Clevers, Organoids and Drug Discovery

Digest 8/7/23

Scientist Stories: Walter Gilbert, Reminisces of Genomics

Digest 8/6/23

Scientist Stories: Uri Alon, Systems Biology

Digest 8/5/23

Scientist Stories: Neeha Zaidi, New Approaches to Cancer Vaccines

Digest 8/4/23

Scientist Stories: Peter Schultz, Playing with the Molecules of Life

Digest 8/3/23

Scientist Stories: James Crowe, The Human Immune System

Digest 8/2/23

Founder Stories: Chad Robins, Co-Founder and CEO of Adaptive Biotechnologies

Digest 8/1/23

Scientist Stories: Tobias Kollmann, The Rules of Immunity

Digest 7/31/23

Scientist Stories: Jesse Bloom, Evolution of Viruses

Digest 7/30/23

Scientist Stories: Jonathan Howe, Super Resolution Microscopy

Digest 7/29/23

Scientist Stories: Hans Clevers, Organoids to Model Human Diseases

Digest 7/28/23

Scientist Stories: Mathew Blurton-Jones, Stem Cell Therapies for Alzheimer's Disease

Digest 7/27/23

Scientist Stories: Andreas Mayer, Quantitative Models of the Adaptive Immune System

Digest 7/26/23

Scientist Stories: Florian Büttner, Machine Learning in Oncology

Digest 7/25/23

Scientist Stories: Pamela Bjorkman, Neutralizing Antibodies Against Coronaviruses

Digest 7/24/23

Scientist Stories: Anant Madabhushi, Using AI to Predict Immunotherapy Response

Digest 7/23/23

Scientist Stories: Mark Davis, Strategies to Study the Human Immune System

Digest 7/22/23

Scientist Stories: Ofer Levy, Precision Vaccines

Digest 7/21/23

Scientist Stories: Jim Allison, Pioneering Immunotherapies

Digest 7/20/23

Scientist Stories: Sylvia Plevritis, Cancer Systems Biology

Digest 7/19/23

Scientist Stories: Christian Eggeling, Super Resolution Microscopy in Biomedical Research

Digest 7/12/23

Scientist Stories: Ricardo Henriques, Super Resolution & Machine Learning in Imaging

Digest 7/11/23

Scientist Stories: Fred Gage, Disease Modeling

Digest 7/10/23

Scientist Stories: Maddy Parsons, Imaging Cytoskeletal Dynamics

Digest 7/9/23

Leadership and Bioengineering with Omar Ali

Synthetic Biology and Rapid Evolution with Chang Liu

Founding Unlearn and Revolutionizing Clinical Trials with Charles Fisher

Imaging Dyes and Microscopy with Luke Lavis

Autonomous Microscopy with Kevin Dean

Biotech Company Building, Partnering, Investing Towards Better Medicines with Vikas Goyal

Founding Hoxton Farms and Creating the Future of Food with Max Jamilly

Founding Y-Trap and Protein Engineering with Rishi Bedi

Founding AgBiome with Eric Ward

Chemistry to Build New Imaging Tools & Probe the Brain with Anand Muthusamy

Proteomics and Deep Learning with Melih Yilmaz

Leadership and Bioengineering with Omar Ali

Synthetic Biology and Rapid Evolution with Chang Liu

Founding Unlearn and Revolutionizing Clinical Trials with Charles Fisher

Imaging Dyes and Microscopy with Luke Lavis

Autonomous Microscopy with Kevin Dean

Biotech Company Building, Partnering, Investing Towards Better Medicines with Vikas Goyal

Founding Hoxton Farms and Creating the Future of Food with Max Jamilly

Founding Y-Trap and Protein Engineering with Rishi Bedi

Founding AgBiome with Eric Ward

Chemistry to Build New Imaging Tools & Probe the Brain with Anand Muthusamy

Scientist Stories: Saar Gill, CAR-T Cell Therapies

Digest 7/8/23

Scientist Stories: Valérie Verhasselt, Early Life Nutrition and Immune Development

Digest 7/7/23

Proteomics and Deep Learning with Melih Yilmaz

Scientist Stories: Carl June, Adoptive Immunotherapy for Cancer

Digest 7/6/23

How Our Microbiomes affect Nutrition & Pharmacology with Peter Turnbaugh

How Our Microbiomes affect Nutrition & Pharmacology with Peter Turnbaugh

Founder Stories: Kiran Mazumdar, Founder of Biocon

Digest 7/5/23

Scientist Stories: Alexandra Pacureanu, From 3D Light to 3D Electron Microscopy

Digest 7/4/23

Founder Stories: John Oyler, Founder and CEO of BeiGene

Digest 7/3/23

Scientist Stories: Ralf Jungmann, Spatial Proteomics and Molecular Imaging

Digest 7/2/23

Scientist Stories: Elaine Mardis, Genomics and Medicine

Digest 7/1/23

Scientist Stories: Jeannie Lee, RNA and the New Genetics

Digest 6/30/23

Founder Stories: Ryan Watts, Co-Founder & CEO of Denali Therapeutics pioneering neuro medicines

Digest 6/29/23

Founder Stories: Özlem Türeci, mRNA and Vaccines

Digest 6/28/23

Founder Stories: Uğur Şahin & Özlem Türeci, Building BioNTech into an Iconic Biotech Company

Digest 6/27/23

Scientist Stories: Joan Steitz, Pioneering Discoveries in RNA & Translation

Digest 6/26/23

Scientist Stories: Jennifer Dionne, Nanophotonics to Visualize Dynamic Processes near Atomic Scale

Digest 6/25/23

Scientist Stories: Eva Nogales, Visualizing Dynamics of Complex Macromolecular Assemblies

Digest 6/24/23

Founder Stories: Roy Vagelos, Biotech legend & former CEO of Merck

Digest 6/23/23

Scientist Stories: Andrew Kruse, GPCRs & Antibody Discovery

Digest 6/22/23

Scientist Stories: Eric Betzig, Historical Connections Between Astronomy and Microscopy

Digest 6/21/23

Founder Stories: John Maraganore, CEO of Alnylam pioneering RNAi therapeutics

Digest 6/20/23

Scientist Stories: Mark Davis, Exploring Human Immunology

Digest 6/19/23

Scientist Stories: David Baker, Design of Protein Structures, Functions & Assemblies

Digest 6/17/23

Scientist Stories: Xin Jin, In Vivo Perturb-seq & Scalable Investigation of Gene Functions

Digest 6/13/23

Scientist Stories: Mark Akeson, The Present and Future of Nanopore Sequencing

Digest 6/12/23

Scientist Stories: Bruno Correia, De novo Design of Proteins

Digest 6/11/23

Founder Stories: George Scangos, former CEO of Biogen and Medical Innovation & Social Responsibility

Digest 6/10/23

Scientist Stories: Elizabeth Villa, Cryo-EM and Studying Parkinson's Disease

Digest 6/9/23

Axial 100 - Glycobiology

Axial 100 - Microscopy & imaging dyes

Founder Stories: John Martin, Former CEO of Gilead Sciences

Digest 6/8/23

Scientist Stories: Carolyn Bertozzi, Therapeutic Opportunities in Glycoscience

Digest 6/7/23

Scientist Stories: Rachel Green, Regulation of Protein Synthesis

Digest 6/6/23

Scientist Stories: Jeff Litchman, Connectomics Across Scales

Digest 6/5/23

Scientist Stories: Anna Greka, Kidney Disease, Genomics & Drug Development

Digest 6/4/23

Scientist Stories: Albert Heck, The Uniqueness of Our Plasma Proteome

Digest 6/3/23

Scientist Stories: Fei Chen, Next Generation Tools for Spatial Genomics

Digest 6/2/23

Scientist Stories: Matthew Hurles, Causes and Consequences of New Mutations in Humans

Digest 6/1/23

Scientist Stories: Tony Wyss-Coray, Brain Aging and Neurodegeneration

Digest 5/31/23

Scientist Stories: Sydney Brenner, Linking Genetic Analysis to Cell Division and Organ Formation

Digest 5/30/23

Founder Stories: Özlem Türeci, mRNA: From Cancer Therapy to Infectious Disease Prevention

Digest 5/29/23

Scientist Stories: Frances Arnold, Innovation by Evolution & Bringing New Chemistry to Life

Digest 5/28/23

Scientist Stories: Herbert "Skip" Virgin, Mammalian Virome in Health and Disease Pathogenesis

Digest 5/27/23

Scientist Stories: David Schaffer, Directed Evolution of Next-Gen AAV Vectors for Gene Therapy

Digest 5/26/23

Scientist Stories: Ido Amit, The Power of Immunology in the Age of Single Cell Genomics

Digest 5/25/23

Scientist Stories: Phil Sharp, Co-Founder of Biogen and Discovering RNA Splicing

Digest 5/24/23

Scientist Stories: Christopher Bartley, Autoantibody Discovery in Neuropsychiatric Syndromes

Digest 5/23/23

Scientist Stories: Katherine Pollard, Statistical Methods to Study the Genome

Digest 5/22/23

Scientist Stories: David Ross, Integrating Neuroscience into 21st Century Psychiatry

Digest 5/21/23

Scientist Stories: Jonathan Pritchard, Human Genetic Variation and Evolution

Digest 5/20/23

Digest 5/19/23

Founder Stories: Nate Gross, Co-Founder of Doximity and Rock Health

Axial Discovery - Marketplaces in Life Sciences

Founder Stories: Emily Leproust, Co-Founder and CEO of Twist Bioscience & Pioneering DNA Synthesis

Scientist Stories: Nicole Gaudelli & Alexis Komor, Inventing CRISPR Base Editing

Scientist Stories: Magdalena Zernicka-Goetz, Human Development and Synthetic Embryos

Scientist Stories: Luke Gilbert, Repurposing CRISPR as an RNA guided DNA binding platform

Scientist Stories: Daniel Nomura, Chemoproteomic Platforms & the Undruggable Proteome

Scientist Stories: David Haig, Evolution of Imprinting

Scientist Stories: Jean-Laurent Casanova, Are Infectious Diseases Only Infectious?

Scientist Stories: David Furman, Systems Immunology of Aging for Precision Medicine

Scientist Stories: Tu Youyou, Artemisinin & the Gift from Traditional Chinese Medicine to the World

Cryoport

Brammer Bio

Forge Biologics

Resilience

Axial Discovery - Royalty aggregators

GreenLight Biosciences

Arbor Biosciences

Debut Biotech

SwiftScale Biologics

EnginZyme

Tierra Biosciences

Sutro Biopharma

CambridgeSoft

Axial Discovery - Phenotypic screening

Founding Infinimmune & Developing Breakthrough Tools for Antibody Discovery with Wyatt McDonnell

Founding Infinimmune & Developing Breakthrough Tools for Antibody Discovery with Wyatt McDonnell

Unlearn

LatchBio

BioRender

Synthace

Benchling

Axial Discovery - Onshoring biomanufacturing

10X Genomics

Pleno

Axial Daily #1 (Biotech Exits)

Oxford Nanopore

PacBio

Illumina

Element Biosciences

Axial Discovery - Immunometabolism

Ultima Genomics

Affinivax

ChemoCentryx

Global Blood Therapeutics

Acceleron

Biohaven

Ablynx

Kymab

Becoming a World-Class Scientist & The Rules of Enzymes with Margaux Pinney

Axial Discovery - Kidney disease

Becoming a World-Class Scientist & The Rules of Enzymes with Margaux Pinney

Papa

Virta Health

AgBiome

Gerty and Carl Cori

Madrigal Pharmaceuticals

Vicki Sato

Dyno Therapeutics

Evotec

Tempus

Flatiron Health

Schrödinger

AskBio

Elektrofi

Abcam

Ligand Pharmaceuticals

XOMA

Royalty Pharma

Geltor

Living Carbon

LanzaTech

Prometheus Biosciences

Insitro

Hexagon Bio

Exscientia

Alloy Therapeutics

Aldevron

Arnold Beckman

Solugen

Horizon Therapeutics

BenchSci

Morphic Therapeutic

Veeva

Absci

Capstan Therapeutics

MyoKardia

Olink Proteomics

Replay Therapeutics

Agios Pharmaceuticals

Culture Biosciences

Prime Medicine

AbCellera

Ginkgo Bioworks

Recursion Pharmaceuticals

Catalyzing Drug Discovery with AI and Scaled Chemical Libraries with Devon Cayer

Building a SaaS Company in Biotech with Abhishek Jha

Immunometabolism, Inflammation and Chemistry Intersecting with Greg Timblin

Image-Activated Cell Sorting with Keisuke Goda

NK Cells and Curing Cancer with Nina Horowitz

Graph Machine Learning and Life Sciences with Hannes Stärk

A Common Language for Therapeutic Synthetic Biology with Justin Farlow

Extrachromosomal DNA and Cancer Development with King Hung

High-Throughput Chemistry and Engineering with Kadi Saar

Machine Learning-Assisted Directed Evolution with Bruce Wittmann

Chemistry to Control Biology & Building a World-Class Lab with Bryan Dickinson

Axial Discovery - N-of-1 trials

Catalyzing Drug Discovery with AI and Scaled Chemical Libraries with Devon Cayer

Axial Discovery - Voice in healthcare

Building a SaaS Company in Biotech with Abhishek Jha

Axial Discovery - Machine learning and DNA-encoded libraries

Chemistry to Control Biology & Building a World-Class Lab with Bryan Dickinson

Axial Discovery - Targeting cardiac fibrosis with engineered T-cells

Immunometabolism, Inflammation and Chemistry Intersecting with Greg Timblin

Axial Discovery - HSC therapies

Axial Discovery - Industrial enzymes

Axial Discovery - AAV biomanufacturing

Axial Discovery - Single-cell sequencing

Axial Discovery - Chemokines