Digest 8/14/23
Surveying great inventors and businesses
Axial: https://linktr.ee/axialxyz
Axial partners with great founders and inventors. We invest in early-stage life sciences companies such as Appia Bio, Seranova Bio, Delix Therapeutics, Simcha Therapeutics, among others often when they are no more than an idea. We are fanatical about helping the rare inventor who is compelled to build their own enduring business. If you or someone you know has a great idea or company in life sciences, Axial would be excited to get to know you and possibly invest in your vision and company . We are excited to be in business with you - email us at info@axialvc.com
A window to the brain: ultrasound imaging of human neural activity through a permanent acoustic window led by Claire Rabut, Sumner Norman, and Whitney Griggs from the Mikhail Shapiro lab https://www.biorxiv.org/content/10.1101/2023.06.14.544094v1
Vault: DiCE Molecules
Exact Sciences:
- Founded in 1995 to develop non-invasive tests for colorectal cancer
- Partnering with Mayo Clinic in 2009 & launching Cologuard in 2014/2015
- A non-invasive stool-based screening test to detect DNA & hemoglobin biomarkers
JT001
An oral NLRP3 inflammasome inhibitor
Discovered from oral efficacy models and related to a phase I candidate GDC-2394 from MCC950 & optimized for lipophilic ligand efficacy
Developed by Jecure and led by Genentech
https://pubmed.ncbi.nlm.nih.gov/37308266/
Methods for multiplex chromatin interaction analysis by droplet sequencing with single molecule precision
Inventors: Meizhen Zheng, Yijun Ruan, Chia-Lin Wei, Zhongyuan Tia
Current Assignee: Jackson Laboratory
https://patentimages.storage.googleapis.com/b1/8d/a6/afd70819065f6f/US11074991.pdf
Neural Modulation Of Autonomic Nervous System To Alter Memory And Plasticity Of The Autonomic Network invented by Jeffrey Ardell https://techtransfer.universityofcalifornia.edu/NCD/30525.html
Nested Therapeutics is hiring a Senior Clinical Trial Manager https://www.linkedin.com/jobs/view/3668014679
Nested Therapeutics is focused on discovering and developing next generation precision oncology small molecule medicines. Characterizing the mechanisms of cryptic mutation clusters in cancer and are advancing drug discovery programs based on a platform that combines insights from genomics, structural biophysics and unique chemical biology.
Scientist Stories: Manolis Kellis, Integrative Analysis of 10,000 Epigenomic Maps
"Isaac Newton knew the calculations. Whereas, if we're discovering drugs, the problem is that we just don't know enough. We really understand very little about human physiology. We don't know how the machine works, so it's not a surprise that when it's broken, we don't know how to fix it. The fact that we ever make a drug that gives favorable effects is a bloody miracle because it's very difficult to understand what went wrong."
- Roger Perlmutter, CEO of Eikon Therapeutics & former president of Merck Research Labs
