Digest 6/20/23
Surveying great inventors and businesses
Axial: https://linktr.ee/axialxyz
Axial partners with great founders and inventors. We invest in early-stage life sciences companies such as Appia Bio, Seranova Bio, Delix Therapeutics, Simcha Therapeutics, among others often when they are no more than an idea. We are fanatical about helping the rare inventor who is compelled to build their own enduring business. If you or someone you know has a great idea or company in life sciences, Axial would be excited to get to know you and possibly invest in your vision and company . We are excited to be in business with you - email us at info@axialvc.com
Alnylam:
- Founded in 2002 to develop RNAi medicines
- Merging with Ribopharma in 2003 & going public in 2004
- Riding out the ups & downs with partnerships & strong IP
- With its 1st drug, patisiran, approved in 2018 for hATTR and 3 other approved medicines
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors led by Timothy Shay from the Viviana Gradinaru lab https://www.science.org/doi/10.1126/sciadv.adg6618
Founder Stories: John Maraganore, CEO of Alnylam pioneering RNAi therapeutics
"You never know when a discovery is going to solve a problem, so you need to keep trying because sometimes, the smallest new insight could solve a new problem. It takes years to appreciate how big of a discovery it really is."
- Kevan Shokat, pioneer for new drugs against KRAS
