Digest 8/16/23
Surveying great inventors and businesses
Axial: https://linktr.ee/axialxyz
Axial partners with great founders and inventors. We invest in early-stage life sciences companies such as Appia Bio, Seranova Bio, Delix Therapeutics, Simcha Therapeutics, among others often when they are no more than an idea. We are fanatical about helping the rare inventor who is compelled to build their own enduring business. If you or someone you know has a great idea or company in life sciences, Axial would be excited to get to know you and possibly invest in your vision and company . We are excited to be in business with you - email us at info@axialvc.com
Single-cell quantification of ribosome occupancy in early mouse development led by Hakan Ozadam from the Can Cenik lab https://www.nature.com/articles/s41586-023-06228-9
Vault: Regenxbio
Alto Neuroscience:
- Founded in 2019 to develop psychiatric drugs and biomarkers
- With their platform to measure EEG/wearable data, behavior, genetics and more to match patients with the right drug
- Targeting 3 key mental health domains: cognition, emotion & sleep
FDA approved Delcath Systems' Hepzato Kit (melphalan/Hepatic Delivery System) as a treatment for adult patients with mUM with unresectable hepatic metastases
A product that administers melphalan directly to the liver through Delcath's Hepatic Delivery System (HDS)
CT3
An irreversible trypanosomal topoisomerase II inhibitor
Showing preclinical efficacy in mouse models of Chagas disease and sleep sickness
Discovered through a phenotypic screen against trypanosomes by Novartis (NITD)
https://www.science.org/doi/10.1126/science.adh0614
Use of translational profiling to identify target molecules for therapeutic treatment
Inventors: Davide Ruggero, Andrew Hsieh, Merritt Edlind
Current Assignee: University of California
https://patentimages.storage.googleapis.com/3a/e3/67/b90e0b9c944aa4/US20190093170A1.pdf
Protein Domains For Modulation Of RNA Stability And/Or Translation invented by Gene Yeo https://techtransfer.universityofcalifornia.edu/NCD/32558.html
Scribe Therapeutics is hiring a principal scientist focused on AAV and mRNA Engineering for CRISPR delivery https://www.linkedin.com/jobs/view/3688418881
Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR platform
Scientist Stories: Scott Fraser, Multiplex Imaging of Cells in their Natural Contexts
"Progress in science depends on new techniques, new discoveries, and new ideas, probably in that order"
- Sydney Brenner, Nobel Prize winner for establishing the genetics of development
