Sitemap - 2024 - Axial

Spatiotemporally programming cytokine immunotherapies through protein engineering

Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide

Rendering protein structures inside cells at the atomic level with Unreal Engine

Constructor Theory

Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection

Deploying synthetic coevolution and machine learning to engineer protein-protein interactions

A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity

Epigenetic theory of aging

PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics

Directed Evolution of Antibodies with Doug Chapnick

Building the Ultimate Patent Assistant with Evan Zimmerman

Improving Software Engineering in Biostatistics with Daniel Sabanés Bové

Euler's polyhedron formula

Dysregulated Lipid Metabolism in Neurodegeneration

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Perspective on the Current State-of-the-Art of Quantum Computing for Drug Discovery Applications

Hit-synthesis-lead optimization

Somatic mutation rates scale with lifespan across mammals

Machine learning-guided mutagenesis

PoET: A generative model of protein families as sequences-of-sequences

Snakemake

LabKey

Roche's neurology strategy

Gompertz–Makeham law of mortality

GPCRs in kidney disease

Transforming biomanufacturing using software with Martin Permin

Engineering Antibodies to Avoid Escape Mutants

The phenotypic landscape of essential human genes

Human Immunology Biosciences

Protein stability promotes evolvability

Margin of Safety

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

MoonLake Immunotherapeutics

Natural Product Synthesis in the 21st Century: Beyond the Mountain Top

Ultralow Background Membrane Editors for Spatiotemporal Control of Phosphatidic Acid Metabolism and Signaling

i-shaped antibody engineering enables conformational tuning of biotherapeutic receptor agonists

Engineering immune tolerance

In vivo human T cell engineering with enveloped delivery vehicles

Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers

A general method to fine-tune fluorophores for live-cell and in vivo imaging

Enlaza Therapeutics

Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides

Scientist Stories: Barbara Treutlein, Tracing and Perturbing Cell Lineages

Detection of Fluorescent Protein Mechanical Switching in Cellulo

Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism

Central Dogma of Molecular Biology

Modular terpene synthesis enabled by mild electrochemical couplings

Scientist Stories: Tu Youyou, Artemisinin & the Gift from Traditional Chinese Medicine to the World

Scientist Stories: Jennifer Lewis, Printing Synthetic and Living Matter in Three Dimensions

Quantifying the daily harvest of fermentation products from the human gut microbiota

A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models

Scientist Stories: Viviana Gradinaru, Targeted Non-Invasive Genetic Therapies for Brain Disorders

Compact RNA sensors for increasingly complex functions of multiple inputs

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration

Founder Stories: Michael Pellini, Co-Founder and CEO of Foundation Medicine

Antibodies to Watch

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

Founder Stories: Ben Buelow, Founder of TeneoBio, The Platform that Keeps on Giving

Immobility-associated thromboprotection is conserved across mammalian species from bear to human

Scientist Stories: Shirley Tilghman, Genetics of Development

Business Development in Biotech

Reconstructing cell histories in space with image-readable base editor recording

10X Genomics, Century of Biology

A general chemical principle for creating closure-stabilizing integrin inhibitors

Founder Stories: Demis Hassabis, AI to Accelerate Scientific Discovery

Scientist Stories: Dana Pe'er, Single-cell Technologies to Address Fundamental Questions in Biology

Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereof

Let the Best Drug Win with Errik Anderson

Scientist Stories: Aviv Regev, Systems Biology

Discovery of sparse, reliable omic biomarkers with Stabl

Drug Approvals in 2023

Cell time: How cells control developmental timetables

Scientist Stories: Polly Fordyce, Microfluidics for High Throughput Biochemistry

CARGO Therapeutics